Sarah Greising, Ph.D., assistant professor at the School of Kinesiology and director of the Skeletal Muscle Plasticity and Regeneration Laboratory (SMPRL), and colleagues published in Scientific Reports. The article, “PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury” is collaborative work with the University of Georgia that evaluated limiting factors in a muscle’s adaptive capacity for rehabilitation after a multi-muscle volumetric muscle loss injury.
Volumetric muscle loss (VML) injury is characterized by a non-recoverable loss of muscle fibers due to ablative surgery or severe orthopaedic trauma, that results in chronic functional impairments of the soft tissue. Currently, the effects of VML on the oxidative capacity and adaptability of the remaining injured muscle are unclear. A better understanding of this pathophysiology could significantly shape how VML-injured patients and clinicians approach regenerative medicine and rehabilitation following injury. Read the full article here.